Chronic morphine drinking establishes morphine tolerance, but not addiction in Wistar rats

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Place Aversion by Morphine in Offspring Born of Female Morphine Administered Wistar Rats

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Place Aversion by Morphine in Offspring Born of Female Morphine Administered Wistar Rats

This research was designed to study sexual differences in place conditioning induced by morphine in offspring born of female Wistar rats mated with drug-naïve males. Mothers were exposed to morphine during the 14th-16th days of gestational. Control dams were simply saline-injected. Female and male virgin offspring born of morphine-treated or saline-treated mothers were separately housed until b...

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Place Aversion by Morphine in Offspring Born of Female Morphine Administered Wistar Rats

This research was designed to study sexual differences in place conditioning induced by morphine in offspring born of female Wistar rats mated with drug-naïve males. Mothers were exposed to morphine during the 14(th)-16(th) days of gestational. Control dams were simply saline-injected. Female and male virgin offspring born of morphine-treated or saline-treated mothers were separately housed unt...

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Ventilation in morphine-maintained rhesus monkeys. II: Tolerance to the antinociceptive but not the ventilatory effects of morphine.

The antinociceptive and ventilatory effects of morphine and other opioid agonists were determined in three rhesus monkeys during a period of morphine maintenance, as well as before and after the chronic exposure to morphine. Before the onset of the daily dosing regimen, morphine increased tail-withdrawal latencies from 50 degrees C water, with an ED50 of 6.4 +/- 2.1 mg/kg. Daily injection of 3....

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Impacts of morphine addiction on spermatogenesis in rats

BACKGROUND There are numerous investigations on wide range of issues that disrupt regulatory spermatogenesis, individuals who are exposed to drug abuse faced infertility and immature spermatogenesis. OBJECTIVE The aim of this study was to evaluate the addiction effects of morphine and its derivatives on rats spermatogenesis. MATERIALS AND METHODS 40 male Wistar rats were randomly divided in...

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ژورنال

عنوان ژورنال: Journal of Zhejiang University SCIENCE B

سال: 2006

ISSN: 1673-1581,1862-1783

DOI: 10.1631/jzus.2006.b0892